Ion-Activated, Gelrite®-Based in Situ Ophthalmic Gels of Pefloxacin Mesylate: Comparison with Conventional Eye Drops
نویسندگان
چکیده
منابع مشابه
A Comparative Evaluation of 0.3% Eye Drops and in Situ Forming Gel of Pefloxacin Mesylate in Experimentally Induced Pseudomonas Conjunctivitis
The authors evaluated and compared the efficacies of eye drops and in situ forming gel of pefloxacin mesylate in pseudomonas induced conjunctivitis in 40 rabbits. The in-situ forming gel of pefloxacin mesylate was formulated as a liquid and when administered in the cul-de-sac, it gets converted to gel. The objective of the present research work was to demonstrate the in vivo activity of in situ...
متن کاملFormulation and Evaluation of in Situ Mucoadhesive Ophthalmic Hydrogel for Sustained Delivery of Pefloxacin Mesylate
Objective: The drawback associated with conventional eye drops needs development of novel ophthalmic delivery system with improved bioavailability and patient compliances. The objective of present work was to develop and evaluate mucoadhesive in situ ocular gel of Pefloxacin mesylate based on the concept of ion activated in situ gelation for the prolonged precorneal residence time. Methods: For...
متن کاملIn-situ Ophthalmic Gels for the Treatment of Eye Diseases
Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of eye. Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks with this route, like non-productive absorption, drainage, induced lacrimation, tear turn over, impermeability of drugs to cornea. New approaches have been inve...
متن کاملIon-activated In Situ Gelling Ophthalmic Delivery Systems of Azithromycin
Gelation of pectin caused by divalent cations especially calcium ions has been applied to develop an ophthalmic formulation of azithromycin in the present study. Rapid elimination of drug on instillation into cul de sac would be minimal with in situ gelling ophthalmic solution leading to increased precorneal contact time and prolonged drug delivery. In the formulation development studies pectin...
متن کاملIn vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin.
The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems, which upon instillation as drops into the eye undergo a sol-gel transition in the cul-de-sac. This may result in better ocular availability of the drug. The purpose of this work was to develop a...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2006
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717540500309164